Surface coil arrays for simultaneous reception and transmission with a volume coil and uses thereof

ABSTRACT

This invention provides arrays of counter rotating current surface coils for simultaneous reception and transmission with a volume coil for improved signal-to-noise ratio and radio frequency field homogeneity for in particular high-field (4-8 T) imaging of deep body regions, such as central brain structures.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a U.S. national stage entry under 35 U.S.C. §371 ofPCT International Patent Application No. PCT/US2007/005453, filed Mar.1, 2007, and claims priority to U.S. Provisional Patent Application No.60/783,125, filed Mar. 15, 2006, the contents of which are incorporatedherein by reference in their entirety.

STATEMENT OF GOVERNMENT SUPPORT

This invention was made with government support under grant numbersM01-RR12248 and R01-EB00473 awarded by the National Institutes of Health(NIH). The government has certain rights in the invention.

FIELD OF THE INVENTION

The present invention relates to arrays of counter rotating current(CRC) surface coils for simultaneous reception and transmission with avolume coil for improved signal-to-noise ratio (SNR) and radio frequency(RF) field homogeneity for imaging. The invention is especially usefulfor imaging deep body regions such as central brain structures at highermagnetic fields (>4 Tesla (T)).

BACKGROUND OF THE INVENTION

Throughout this application various publications are referred to inparenthesis. Full citations for these references may be found at the endof the specification immediately preceding the claims. The disclosuresof these publications are hereby incorporated by reference in theirentireties into the subject application to more fully describe the artto which the subject application pertains.

Magnetic resonance imaging (MRI) is widely used in clinical diagnosis.The SNR of a magnetic resonance image is dependent on a number offactors. A common way to improve SNR from restricted regions is by usinga transmit-only volume coil with a receive-only surface coil phasedarray (1). Since their introduction by Roemer and colleagues (1), phasedarrays have proven to be effective in extending the high sensitivity ofa single surface coil to a much larger field-of-view (FOV). Due tostrong coupling between surface coils in the phased array and the volumetransmit coil, the volume coil is used as a “transmit-only” coil,typically being detuned during reception. Although phased arrays havesuperior SNR near the surface coils, it has not been possible to achievesubstantial SNR increases in comparison to optimized head-sizequadrature volume coils from central regions (7-8 cm depth) of the humanhead (2, 3). The region of increased SNR afforded by the arrays can beextended to include the center of the brain if the signals from anoptimized volume coil can be combined with those from the array duringsimultaneous reception. However this combination can only yieldsignificant improvements if 1) the interaction between the volume coiland the surface coil does not substantially degrade the performance ofeither coil and 2) if the noise acquired by each coil is uncorrelated.

Previously, Kocharian and colleagues employed simultaneous receptionwith conventional single-loop surface coils using a body coil (4) and ahead volume coil (5). The authors did not evaluate quantitatively thechange in the SNR due to simultaneous reception as compared with thesurface coils alone. However, mutual inductive coupling between thevolume coil and the single-loop surface coil altered the RF magneticfield B₁ profiles of both coils (5), which would have substantiallydecreased the overall array performance (6). Furthermore, as the size ofthe volume coil was reduced to be optimal for heads (5), the inductivecoupling between the volume coil and the surface coils increased,thereby further reducing the SNR benefits of the array. Thus, in generalsingle-turn surface coils when used in combination with volumes coilsfor simultaneous reception yield no or minimal increases in SNR.

To avoid interactions between the volume and the surface coils, Hyde andcolleagues have reported a counter rotating current (CRC) surface coilconsisting of two parallel rings carrying opposite currents (7). Theopposing currents provide intrinsic isolation between the surface coiland the volume transmit coil, which enables simultaneous reception byboth coils with improved SNR in areas where they have similarsensitivities. Although the CRC coil has much lower sensitivity than asingle-turn coil of the same size when unloaded, when loaded such thatsample losses dominate, the CRC's sensitivity becomes virtuallyindistinguishable from a single-turn surface coil at distances greaterthan approximately the distance between the two loops of the CRC coil(7). Simultaneous reception using a single CRC coil and a transmitvolume coil has been demonstrated previously (8, 9); however, prior tothe present invention, the configuration has not been extended tomultiple CRC coils in phased arrays. Gradiometer coils, also consistingof two loops with opposite currents, have been described and usedpreviously for nuclear quadrupole resonance (NQR) and low-field magneticMRI applications (10, 11) to reduce the injected noise.

At higher fields (4 T and above), the sensitivity profile of ahead-sized volume coil can be substantially altered due to RFfield/tissue interaction (26-28). A very characteristic pattern with theRF magnetic field enhanced at the center of a human brain has beenobserved at 4 T (20, 26) and was even more pronounced at 7 T (26). SNRmeasured in the center of the central transaxial slice of the head washigher by 30% at 4 T (20, 26) and by 75% at 7 T (26) as compared to theperipheral SNR. Attempts to compensate the RF transmit fieldinhomogeneity both numerically (29, 30) and experimentally (31) havebeen made using multi-port excitation of a single volume coil (29) or ofa tranceive phased array (30, 31). These methods improve fieldhomogeneity due to combining a homogeneous mode with higher order modesproduced by multi-mode volume coils or tranceive phased arrays, butresult in substantial phase distortion. Thus, there remains a need forimproved radio frequency (RF) field homogeneity and signal-to-noiseratio (SNR) enhancement for body imaging, especially for imaging deeperregions such as central brain structures.

SUMMARY OF THE INVENTION

The present invention provides surface coil arrays for simultaneousreception of a radio frequency magnetic field signal with a volume coilduring imaging, where the array comprises a plurality of counterrotating current (CRC) coils arranged for positioning over the surfaceof a region to be imaged, wherein each CRC coil contains two loops wherecurrent flows in opposite direction in each loop, and wherein the CRCcoil array provides simultaneous reception of the radio frequencymagnetic field signal with the volume coil during imaging.

The invention also provides surface coil phased arrays for simultaneoustransmission and reception of a radio frequency magnetic field signalwith a quadrature volume coil during imaging, where the array comprisesat least four counter rotating current (CRC) coils uniformly arrangedfor positioning around the surface of a region to be imaged, whereineach CRC coil contains two loops where current flows in oppositedirection in each loop, wherein the radio frequency magnetic fieldtransmitted by an individual coil is shifted out of phase with the radiofrequency magnetic field transmitted by adjacent coils to produce acircularly polarized radio frequency magnetic field that is in phasewith a circularly polarized radio frequency magnetic field generated bythe quadrature volume coil, and wherein the CRC coil phased arrayprovides simultaneous transmission and reception of the radio frequencymagnetic field signal with the volume coil during imaging.

The invention further provides radio frequency systems for imaging wherethe systems comprise any of the surface coil arrays disclosed herein anda quadrature volume coil.

The present invention also provides methods of imaging a region of asubject, where the methods comprise simultaneously receiving, orsimultaneously transmitting and receiving, a radio frequency magneticfield signal by a surface coil array and by a volume coil.

The apparatus and methods disclosed herein provide improvedsignal-to-noise ratio and improved radio frequency magnetic fieldhomogeneity during imaging.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1. Schematic of the CRC surface coil matching network includingpreamplifier decoupling.

FIG. 2A-2B. Views of (A) the four-channel CRC phased arraycircumscribing a human head and (B) the same phased array assembledtogether with the head-sized TEM volume coil for simultaneous use duringtransmission and reception.

FIG. 3A-3C. Performance of a conventional single-turn surface coil usedfor simultaneous reception with a volume coil. A) The map of the ratioof regular single-turn surface coil gradient echo phantom imagesobtained during the volume/surface coil simultaneous reception and withthe volume coil detuned during the reception. B) The central verticalplots of the surface coil images obtained during the volume/surface coilsimultaneous reception (dashed line) and with the TEM volume coildetuned (solid line). C) The map of the ratio of TEM volume coil imagesobtained during the volume/surface coil simultaneous reception and withthe surface coil detuned.

FIG. 4A-4B. CRC coil performance. A) Central vertical plots of gradientecho phantom images obtained using 7.5×8 cm CRC coils with differentdistances between the loops. Distance between loops=12 mm (solid line),9 mm (dashed line), 6 mm (dotted line). B) Central plots of the phantomimages obtained by the CRC coil (solid line) and the regular single-turnsurface coil (dashed line) of the same size. The inset in B) shows anexpanded view of the initial portion of the larger plot.

FIG. 5A-5E. Imaging data for a phantom mimicking the load of a headduring simultaneous reception using the TEM volume coil and CRC coil.Gradient-echo phantom images from the TEM obtained during the TEM andthe CRC coil simultaneous reception without (A) and with preamplifierdecoupling (B). C) Central vertical plots of volume coil images shown in(A) (dashed line) and (B) (solid line). D) The map of the ratio of theCRC coil gradient echo images obtained during the volume/surface coilsimultaneous reception and with the volume coil detuned during thereception. E) Central plots of the CRC coil phantom images obtained withthe TEM coil detuned (solid line) and during the CRC/TEM simultaneousreception (dashed line).

FIG. 6. Central vertical plot of phantom images from the TEM coil(dotted line) and the CRC array (dashed line) as well as theirsum-of-squares (SoS) combination (solid line) obtained during the TEMvolume coil and the CRC array simultaneous reception.

FIG. 7A-7E. Human head images from the TEM (A) and individual CRCsurface coils (B-D) obtained during the TEM volume coil and thethree-channel occipital CRC array simultaneous reception. E) SoScombined image.

FIG. 8. Improvement of SNR in the SoS-combined image, shown in FIG. 7E,calculated at each point as a ratio of the SoS SNR to the largest SNRbetween two of the coils (either TEM or the occipital CRC array).

FIG. 9A-9F. Human head images from individual CRC surface coils (A-D)and the TEM volume coil (E) obtained during the TEM/four-channel CRCarray simultaneous reception. F) SoS-combination of all five images.

FIG. 10A-10B. Improvement in SNR obtained by simultaneous reception withfour-channel CRC array and the volume coils. A) Improvement of SNR inthe SoS combined image calculated at each point as a ratio of the SoSSNR to the largest SNR between two of the coils (either TEM or the CRCarray). B) The map of the ratio of the four-channel CRC array SNR to theSNR of the TEM coil.

FIG. 11. Schematic of the simultaneous transmission and reception with aCRC phased array and a volume coil.

FIG. 12A-12B. Transmit B₁ field improvement obtained for a human headduring simultaneous transmission from the volume coil and thefour-channel CRC array. A) Transmit B₁ field obtained by the TEM volumecoil alone. B) Transmit B₁ field obtained with simultaneous transmissionfrom the volume coil and the array using a transmit power ratio of 2:1.

FIG. 13A-13B. Transmit B₁ field improvement obtained for a 3 L phantomwith simultaneous transmission from the volume coil and the four-channelCRC array. Conditions mimic those seen in the human head at higher fieldstrength of 7T. A) Transmit B₁ field obtained by the TEM volume coilalone. B) Transmit B₁ field obtained with simultaneous transmission fromthe volume coil and the array using a transmit power ratio of 1:1.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides surface coil arrays for simultaneousreception of a radio frequency (RF) magnetic field signal with a volumecoil during imaging, where the array comprises a plurality of counterrotating current (CRC) coils arranged for positioning over the surfaceof a region to be imaged, wherein each CRC coil contains two parallelloops where current flows in opposite direction in each loop, andwherein the CRC coil array provides simultaneous reception of the radiofrequency magnetic field signal with the volume coil during imaging.

The invention also provides surface coil phased arrays for simultaneoustransmission and reception of a radio frequency (RF) magnetic fieldsignal with a quadrature volume coil during imaging, where the arraycomprises at least four counter rotating current (CRC) coils uniformlyarranged for positioning around the surface of a region to be imaged,wherein each CRC coil contains two parallel loops where current flows inopposite direction in each loop, wherein the radio frequency magneticfield transmitted by an individual coil is shifted out of phase with theradio frequency magnetic field transmitted by adjacent coils to producea circularly polarized radio frequency magnetic field that is in phasewith a circularly polarized radio frequency magnetic field generated bythe quadrature volume coil, and wherein the CRC coil phased arrayprovides simultaneous transmission and reception of the radio frequencymagnetic field signal with the volume coil during imaging.

In different examples, the surface coil arrays comprise 3 to 64 CRCcoils. In another example, the surface coil arrays comprise at least 8CRC coils.

The surface coil array is intrinsically decoupled from the volume coildue to the presence of the two counter rotating loops in each coil.

Preferably, the distance between the loops of each CRC coil is adjustedto optimize i) decoupling between the CRC surface coils in the array andthe volume coil and ii) sensitivity of the CRC coil for reception. Thedistance between loops of each coil can be optimized according to coilgeometry and imaging conditions, for example according to the diameterof loop and the resonance frequency of the coil.

CRC coils of different size can be used in the present invention. As anexample, the CRC coils can have a diameter of 7.5 cm and a separationbetween coils of 12 mm. In another example, the coils can have adiameter of 10 cm and a distance between coils of 9 mm.

In one preferred example, a ratio Q_(U)/Q_(L) between the unloadedQ-factor (Q_(U)) and the loaded Q-factor (Q_(L)) of at least 2.0 wasdemonstrated to be sufficiently large to provide conditions whensensitivity of the CRC surface coil is not compromised as compared to asingle-loop surface coil of similar size,

where

$Q_{L} = {\omega_{0}\frac{W_{t}}{P_{sample} + P_{coil}}}$ and${Q_{U} = {\omega_{0}\frac{W_{t}}{P_{coil}}}},$

-   -   ω₀ is the resonance frequency, W_(t) is the total magnetic field        energy, and P_(sample) and P_(coil) are sample and coil energy        losses, respectively.

Preferably, preamplifier decoupling of the CRC coils provides additionaldecoupling between surface coils in the array and reduces volume coilradio frequency (RF) magnetic field distortions due to residualvolume/CRC coil interaction. For example, the distortion may be reducedto be less than 5% over the entire imaging field.

Preferably, simultaneous reception of the radio frequency magnetic fieldsignal by the surface coil array and by the volume coil results in anincrease in signal-to-noise ratio (SNR) up to square root of 2 in areaswhere the surface coils and the volume coil have similar sensitivity,compared to the SNR obtained by a volume coil or an array in the absenceof simultaneous reception. For the surface coil phased arraycircumscribing a head, the area of similar sensitivity will be near thecenter of the region that is being imaged.

Preferably, the homogeneity of the transmitted radio frequency magneticfield is improved by simultaneous transmission of the radio frequencymagnetic field by the surface coil array and by the volume coil,compared to the homogeneity in the absence of simultaneous transmission.For example, due to RF field/tissue interactions at high magnetic fieldstrengths (4-8 Tesla), the transmit field from head-sized volume coilsshows a distinctive pattern of inhomogeneity, with enhanced sensitivityin the center of the brain. Transmit field inhomogeneity is compensatedin the present invention by using simultaneous transmission with avolume coil and a CRC phased array.

The invention also provides a radio frequency (RF) system for imagingcomprising any of the surface coil arrays disclosed herein and aquadrature volume coil. Different types of quadrature volume coils maybe used. Examples include a transverse electromagnetic (TEM) volume coiland a birdcage volume coil (18). The RF system can be used with magneticfields of different strength, for example between 4 Tesla and 8 Tesla.

The invention also provides a method of imaging a region of a subjectcomprising simultaneously receiving a radio frequency magnetic fieldsignal by any of the surface coil arrays disclosed herein and by avolume coil. The invention further provides a method of imaging a regionof a subject comprising simultaneously transmitting and receiving aradio frequency magnetic field signal by any of the surface coil phasedarrays disclosed herein and by a quadrature volume coil. The methodsdisclosed herein are especially useful for imaging deeper regions of thebody, for example brain regions such as central brain regions.

This invention will be better understood from the Experimental Details,which follow. However, one skilled in the art will readily appreciatethat the specific methods and results discussed are merely illustrativeof the invention as described more fully in the claims that followthereafter.

EXPERIMENTAL DETAILS Theory

The intrinsic decoupling of the CRC coil from a homogeneous volume coiland comparison of the CRC coil sensitivity with the sensitivity of thesingle-turn surface coil of the same size has been discussed previously(7). However, the absence of mutual inductive coupling does notnecessarily guarantee the absence of noise correlation (1), which isrequired for increased SNR during simultaneous reception (8). It hasbeen shown previously that two overlapping vector magnetic fieldprofiles, B₁ and B₁′, produce no noise correlation if the integral oftheir scalar product over the entire sample equals zero (13, 14), i.e.∫B ₁ B ₁ ′dV=0  [1]

This is similar to criteria for orthogonality of eigenfunctions (15).Notably this does not require that the two vectors, B₁ and B₁′, areorthogonal at every single point within the sample. Examples of arraysof orthogonal volume coils placed inside each other and having similarsensitive volumes include: i) a combination of a regular bird cage BCcoil with two spiral BC coils having ±2π rung revolutions along centralaxis (16) and ii) a combination of two ±π BC volume coils (17).

For a single CRC and a volume coil, Equation [1] can be rewritten as∫B _(1CRC) B _(1volume) dV=∫(B _(1CRC) ^(top) −B _(1CRC) ^(bottom))B_(1volume) dV=0,  [2]where B_(1CRC) ^(top) and B_(1CRC) ^(bottom) are the fields produced bythe two loops of the CRC coil. For locations distant from the CRC coil(distances much greater than the distance between the loops), themagnetic fields produced by each loop of the CRC coil are nearly equalin magnitude but opposite in sign and thus cancel each other. However,near the CRC coil the two values differ and give a nonzero contributionto the integral of their product. Decreasing the distance between twoloops minimizes this contribution, thereby decreasing the possible noisecorrelation with the volume coil.

Previously it has been demonstrated at 1.5 T that although the unloadedCRC coil has much lower sensitivity than a single-turn surface coil,when loaded such that sample losses dominate, the CRC and thesingle-turn coil sensitivities become nearly identical at depths greaterthan approximately the distance between the two loops of the CRC coil(7). To assess the degree to which sample losses dominate i.e.P_(sample)/P_(coil), where P_(sample) and P_(coil) are sample andintrinsic coil losses, respectively, definitions of the loaded, Q_(L),and unloaded, Q_(U), Q-factors can be used, where

$\begin{matrix}{{{Q_{L} = {\omega_{0}\frac{W_{t}}{P_{sample} + P_{coil}}}},{and}}{Q_{U} = {\omega_{0}\frac{W_{t}}{P_{coil}}}}} & \lbrack 3\rbrack\end{matrix}$where ω₀ is the resonance frequency and W_(t) is the total magneticfield energy. After simple algebra, one obtains

$\begin{matrix}{\frac{P_{sample}}{P_{coil}} = {\frac{Q_{U}}{Q_{L}} - 1.}} & \lbrack 4\rbrack\end{matrix}$The ratio of Q_(U)/Q_(L) can be measured experimentally and serves as aparameter that determines the extent of sample loss domination.Decreasing the distance between the loops of the CRC coil decreasesnoise correlation between the volume coil and the CRC coil. It alsoimproves the isolation between the CRC and the volume coil by decreasingthe residual mutual inductive coupling due to inhomogeneity of thevolume coil. At the same time, bringing the loops of the CRC coil closerto each other decreases the sample loss contribution, which cancompromise the performance of the CRC coil. The CRC coil's Q_(U) sets alower limit for the optimal distance between the CRC loops. Thus,minimizing intrinsic coil losses can become an important issue.Methods

A head-sized 16-element actively detunable quadrature transverseelectromagnetic (TEM) volume coil (19, 20) was used for transmission(diameter at the element centers −31.8 cm, shield diameter −38 cm,length 23.9 cm). Detailed descriptions of the volume coil design andconstruction have been described previously (20). Although activedetuning of the volume coil is not required for the TEM/CRC arraycombination, it was included in the coil to enable evaluation of thecoil performance with and without simultaneous reception. For comparisonpurposes all surface coils and phased arrays also had active detuningincorporated into their design so as to allow the volume coil receptionefficiency to be used as a reference.

Before constructing the phased array, the performance of the CRC coilwas characterized as a function of loop separation by adjusting thedistance between the loops. Four CRC coils (8×7.5 cm) with loopsseparation of 6, 9, 12 and 16 mm were constructed. A conventionalsingle-turn surface coil of the same size was also built for comparisonpurposes. No preamplifier decoupling was utilized in these surfacecoils.

A three-channel occipital CRC array was built using 6.4 mm wide coppertape (33). Each surface coil measured 8×7.5 cm and consisted of twooctagonal coplanar loops separated by 12 mm. Two loops of the CRC coilwere connected in series to produce two currents flowing in oppositedirection as shown in FIG. 1. Three capacitors were uniformlydistributed over both loops. When placed on acrylic holder of 20.3 cm idwith 10 nm distance between the adjacent CRC coils, the array covered anarc of 138°. The intrinsic decoupling between surface coils was 8-9 dB.Using low input impedance preamplifiers (input impedance ˜4 Ohm)provided better than 20 dB isolation between the surface coils.Preamplifiers were purchased from Advanced Receiver Research(Burlington, Conn.) and modified as described by Beck et al. (21).Preamplifiers were mounted at the volume coil and were protected duringthe transmission by active detuning of the surface coils and by crossdiodes placed at the preamplifiers' inputs. A schematic of the CRC coiland the matching network connecting each surface coil to thepreamplifier is shown in FIG. 1. FIG. 1 depicts a single CRC surfacecoil and corresponding matching network including preamplifierdecoupling schematics. The matching network commonly consists of alumped element quarter wavelength (λ/4) transformer (1, 22, 23), whichconverts the coil resistance to 50 Ohm. Since in the present case theCRC coil resistance at resonance frequency, R_(CRC), is about 3-4 Ohm,the characteristic impedance of the transformer, Z₀, should be onlyabout 13 Ohms (1, 24). In this work, the approach of Beck et al. (21)was used to increase the impedance of the λ/4 transformer and,correspondently, the values of the inductors. As shown in FIG. 1, threeλ/4 transformers connected in series replace a single lumped elementtransformer. With impedances of the first and the third transformers (Z₁and Z₃) equal to 50 Ohm the impedance of the central transformer, Z₂,can be calculated as Z₂=(Z₁Z₃)²/Z₀≈(50)²/13≈200 Ohm. Tri-axial balunswere used for each channel to prevent shield currents. PIN diode(MA4P4006, M/A-COM, Lowell, Mass.) detuning circuits were incorporatedinto each CRC coil to protect preamplifiers during the transmission andto enable comparison of coils' sensitivities with and withoutsimultaneous volume/surface coil reception. For active detuning of eachCRC surface coil PIN diode traps were used as shown in FIG. 1 (20, 23).The coil is decoupled when a high-impedance resonance trap, formed bythe λ/4 transformer and the forward driven PIN diode is introduced inseries with the surface coil. A homebuilt PIN diode driver provideddirect current of 70 mA per diode and a negative bias of 90V.

A phased array circumscribing the head consisting of four 9×10 cm CRCsurface coils is shown in FIG. 2. Each CRC coil was actively detuned anddriven as depicted in FIG. 1. To provide better fit and to optimize theCRC array performance, the 20.3 cm (outside diameter) coil holder wassplit in two halves with the position of the top portion beingadjustable vertically (FIG. 2A). The performance of the four-channel CRCphased array was compared to the receive-only array of regularsingle-loop surface coils of the same size and geometry. Adjacent coilswere inductively decoupled and each coil was individually tuned andmatched. No preamplifier decoupling was employed in this design.

The noise correlation function was measured for all of the coils. Noiseimages were obtained by acquiring the images without a RF pulse. Forphantom imaging a 2 L (16 cm OD)) spherical “head phantom” filled with50 mM NaCl (conductivity −0.65 S/m) was used.

All data were acquired with a Varian INOVA 4T (170 MHz) whole-bodysystem (Palo Alto, Calif.). Gradient echo images of phantoms wereobtained with 128×128 resolution. Anatomical images were acquired usingan inversion recovery gradient echo sequence (TE/TIR/TR 14.5/85012500ms) with a matrix size of 256×256, a FOV of 192×192 mm and a slicethickness of 1.5 mm.

Results and Discussion

Performance of the Volume Coil. The performance of the quadrature TEMvolume coil was compared with other volume coils. The TEM coil generateda circular polarized RF magnetic field B₁ of 1 kHz (or 23.5 μT) inamplitude in the central transaxial slice of a human head using 1 kW RF.This is similar or better than previously reported for an activelydetunable quadrature TEM head volume coil of similar size (diameter atthe element centers −32 cm, shield diameter −38 cm, length 25 cm) thatprovided 300 μs 90° pulse in the central transaxial slice of the headusing 1 kW RF power (19). This corresponds to the B₁ field amplitude of0.84 kHz (or 20 μT). The effectiveness of the quadrature TEM volume coilin producing circular polarized RE magnetic field was evaluated using aB₁ mapping method (25). Measurements were performed with the CRC arraypositioned inside of the volume coil. The ratio of the B₁ ⁺ and B₁ ⁻components of the circular polarized magnetic field rotating clockwiseand counter clockwise, respectively, was better than 10 dB over theentire human head and measured 14 dB in the brain center. This indicatesthat the average loss of the amplitude of the transmit B₁ ⁺ field due tothe contribution of the B₁ ⁻ component was less than 5%.

Performance of Conventional Single-Turn Surface Coils when Used forSimultaneous Reception. To provide a basis for direct comparison of theperformance with the CRC coils, the loss in sensitivity for a volume anda conventional surface coil were evaluated when a 7.5×8 cm single-turnsurface coil was placed inside of the TEM volume coil and both coilswere used simultaneously for reception. FIG. 3 shows data obtained froma phantom mimicking a head load using this coil configuration. FIG. 3Adisplays the ratio of the surface coil images obtained with and withoutsimultaneous reception from the TEM and surface coil. The sensitivity ofthe surface coil is decreased by approximately 40% near the coil. FIG.3B shows two central plots obtained from surface coil images recordedusing volume/surface coil simultaneous reception (dashed line) and withthe TEM coil detuned (solid line) during reception. Similarly, the fieldprofile of the volume coil was altered when both coils were usedsimultaneously. FIG. 3C plots the ratio of TEM volume coil imagesobtained with and without simultaneous reception. In this case thevolume coil sensitivity profile is also disturbed both near the surfacecoil and at distant locations. Using preamplifier decoupling of thesurface coil substantially improved the volume coil sensitivity profilebut essentially did not change the surface coil field profile. The noisecorrelation measurements revealed substantial mutual inductive couplingbetween the volume and the surface coils, which manifested in a large(˜0.3-0.4) value of the imaginary part of the noise correlationfunction. The resistive component was about 0.1. However, even if thenoise correlation had been negligible, the mutual inductive coupling ofthe coils still compromised the sensitivity of the surface coil, thusreducing the advantage of simultaneous reception with conventionalsingle turn surface coils.

CRC Coil Performance. To optimize the performance of the individual CRCcoils, a comparison was made of 4 coils with loop sizes of 8×7.5 cm andloop spacings of 6, 9, 12 and 16 mm. FIG. 4A shows the central plots ofphantom images obtained using these coils in receive-only mode with thevolume coil detuned during the reception. The phantom was positioned 1.5cm away from the coils to mimic experimental conditions for brainimaging. Table 1 provides the measured values for isolation between thevolume and the CRC coils, the Q_(U) and the Q_(U)/Q_(L), whichcharacterizes the sample loss contribution. Since increasing the Q_(U)increases the Q_(U)/Q_(L), as well as relative contribution of thesample losses, its optimization becomes an important issue. This wasachieved by minimizing the number of distributed capacitors and usinghigh-Q inductors in the matching network (FIG. 1). As seen from Table 1,the Q_(U) value of the CRC coil decreased with decreasing the distancebetween the loops. The Q_(U) of the conventional single-turn surfacecoil measured 350, which was the same as the Q-value of the CRC coilwith 16 mm loop spacing and only slightly larger than that of the CRCcoil with a 12 mm spacing. Decreasing the distance between the loopsimproves isolation but at the same time decreases the sample losscontribution. For Q_(U)/Q_(L) less than 2 the coil performance decreasedsubstantially (FIG. 4A). The coil with a loop spacing of 6 mm andQ_(U)/Q_(L) equal to 1.6 performed about 40% worse than the CRC coilwith a loop spacing of 12 mm, while the coil with a loop spacing of 9mm, which provided Q_(U)/Q_(L) equal to 2, was only slightly worse. Theperformance of the coil with a loop spacing of 16 mm (not shown) was thesame as the coil with 12 mm loop spacing. Thus a Q_(U)/Q_(L)>2 (orP_(sample)≧P_(coil)) for an 8×7.5 cm CRC coil appears to be optimal.

TABLE 1 Dependence of the loaded Q-factor, Q_(L), and the isolationbetween the volume and the CRC coils on the distance between two loopsof the CRC coil. Distance between loops (mm) Q_(U) Q_(U)/Q_(L) ^(a)Isolation, dB^(b) 16 350 3.1 −15 12 340 2.6 −18 9 305 2 −19 6 275 1.6−21 ^(a)CRC coils were loaded with a 2.0 L spherical phantom located at~1.5 cm distance from the coil surface. ^(b)Isolation was measuredbetween CRC and the quadrature TEM coils with the 90°-hybrid installed.

The sensitivity of the CRC coil was also compared to the regularsingle-loop surface coil of the same size. FIG. 4B shows the centralplots of phantom images obtained using the regular single-turn surfacecoil and the CRC coil with 12 mm distance between the loops. The CRCcoil sensitivity was lower than that of the regular surface coil at thedepths less than 2 cm. At greater depths both coils had similarsensitivities. The decrease in sensitivity immediately adjacent to theCRC coil can be advantageous for human brain spectroscopic studies sincecontamination arising from the scalp and muscle can be decreased. Theintrinsic isolation between the volume coil and CRC coil varied fromabout 15 dB for the coil with a 16 mm loop separation to about −22 dBfor the coil with a 6 mm loop separation. For these reasons, the CRCcoil with 12 dB distance between the loops was chosen, which providedisolation of about −17 to −18 dB but did not significantly compromisethe coil performance. This is in contrast to the less than −10 dB ofisolation between the volume coil and a regular single-turn coil of thesame size that leads to substantial distortions of B₁ field profilesfrom both the surface coil and the volume coil (FIG. 3).

At higher fields when sample loss contribution becomes greater or underexperimental conditions, which allow decreasing the distance between thecoil and the sample thereby increasing the Q_(U)/Q_(L) ratio (or sampleloss contribution), CRC coils with smaller distances between the loopscan be utilized.

FIG. 5 displays imaging data for a phantom mimicking the load of a headobtained during simultaneous reception using the TEM and the CRC coil(12 mm loop separation). As seen from FIGS. 5A-5C, the B₁ profile of thevolume coil was substantially altered near the CRC coil up to a depth of˜5 cm. However, preamplifier decoupling of the CRC coil minimized theTEM coil B₁ field distortions making them less than 5% over the entireFOV (FIG. 5B). FIG. 5D displays the ratio of the CRC coil imagesobtained with and without simultaneous reception from the TEM and theCRC coil. The sensitivity of the CRC coil was altered by less than 10%near the coil (FIG. 5D) with a small decrease in the sensitivity at˜9-10 cm depth (FIG. 5E). Noise measurements did not reveal anysubstantial correlation (<0.05) between the volume and the CRC surfacecoils.

Performance of the Occipital Array and Simultaneous Reception. FIG. 6shows the central plots of phantom images obtained simultaneously by theTEM volume coil and the occipital three-channel CRC array as well as theplot of their sum-of-square (SoS) combination (1). This figuredemonstrates a 40% increase in the SNR at about 8 cm depth near thephantom center. FIG. 7 displays human head images also obtained duringsimultaneous reception with the TEM volume coil and the occipital CRCarray. All images are displayed using the same intensity scale todemonstrate the improvement in SNR from deeper structures within thebrain due the volume coil/CRC array simultaneous reception. The noisecorrelation between the volume and the surface coils was measured to beless than 0.1 in agreement with the phantom data.

FIG. 8 shows the map of the SNR improvement in the SoS combined imagecalculated at each point as a ratio of the SoS SNR to the largest SNRfrom either of the two coils used independently (either TEM or the CRCarray). Similar maps were obtained with the head phantom. About 40%. SNRimprovement near the head and phantom centers was achieved.

Performance of Circumscribing CRC Array and Simultaneous Reception. Toevaluate if the sensitivity of the phased array from central brainregions was not compromised by the use of CRC coils, and provide thereference for quantitative analysis of the CRC array performance,performance was first evaluated for the four-channel receive-only arrayof conventional single-turn surface coils of the same size and geometry.The SNR of the array of four 9×10 single-turn surface coils, measured inthe center of the head, was about 10% better than the TEM volume coil.

Simultaneous reception was evaluated using a circumscribing array offour 9×10 cm CRC coils (FIG. 2) uniformly distributed around the head tooptimize the SNR of the phased array at the center of the brain. FIG. 9depicts a human head image obtained by TEM and each CRC coil duringsimultaneous volume coil/array reception as well the SoS-combination ofall five images. All images are displayed using the same intensity scaleto demonstrate the improvement in peripheral SNR as well as SNRenhancement near the head center. The noise correlation between all theCRC coils in the array as well as between the CRC and the TEM coil wasmeasured to be less than 0.1 in agreement with predictions.

FIG. 10A shows the improvement in SNR obtained by simultaneous receptionwith the array and volume coil calculated as a ratio of the SoS SNR tothe largest SNR of the coils individually (either TEM or the CRC array).About 40% improvement was obtained near the center of the head. FIG. 10Bpresents a map calculated as a ratio of the SNR of the CRC array to theSNR of the TEM coil. At the center of the head the CRC array wasslightly (8%) more effective than the TEM coil. The SNR of the array offour single-turn surface coils, measured in the center of the head, wasonly marginally better (less than 5%). This again confirms theobservation that when sample loss dominates, the CRC array provides verysimilar performance to that of an array of single-turn coils.

Simultaneous Transmission with the CRC Array and a Volume Coil. Due toRF field/tissue interactions at high-field (4-8T), the transmit fieldfrom head-sized volume coils shows a distinctive pattern ofinhomogeneity, with enhanced sensitivity in the center of the brain.Transmit field inhomogeneity was compensated in the present study byusing simultaneous transmission with a volume coil and a CRC phasedarray. Since phased array provides higher peripheral sensitivity than avolume coil (FIG. 10B), a smaller amount of power directed into the CRCarray during transmission will enhance the peripheral RF magnetic fieldimproving overall homogeneity.

FIG. 11 presents a schematic of the simultaneous transmission andreception with a CRC phased array and a volume coil. For simplicity,only four CRC coils are shown in the figure. Increasing the number ofcoils will further improve peripheral homogeneity. During transmission,some amount of the RF power is directed into the CRC phased array usinga directional coupler. If required, a variable attenuator providesfurther attenuation. A four-way splitter delivers equal amount of powerto each CRC coil in the array. Phase shifters provide proper summationof RF magnetic fields created by each individual surface coil to producea circularly polarized field. During reception, signals from all the CRCsurface coils and the volume coil are directed to preamplifiers throughTIR switches (FIG. 11), which also protect preamplifiers duringtransmission.

The intrinsic decoupling between surface coils loaded with a head or aphantom was better than −20 dB. Low input impedance preamplifiers (inputimpedance ˜4Ω) were used to optimize the system performance. Theintrinsic isolation between the volume and CRC coils was better than −17dB. During transmission, the RF power was split in between the TEM andthe phased array. The phases of RF were adjusted so as to provide 0°,90°, 180°, and 270° phase shifts at the corresponding coils in thearray. The phase shift between the TEM and the array was adjusted usinga cylindrical phantom and a pickup coil to provide proper summationbetween circularly polarized fields created by the array and the volumecoil. The transmission network consisted of a four-way splitter and fourT/R switches, enabling delivery of RF power to the array duringtransmission and connection of the surface coils to the preamplifiersduring reception. This enables both simultaneous transmission andreception with the CRC array and the TEM volume coil.

FIG. 12 shows the transmit B₁ field obtained at 4 T by the TEM volumecoil alone (FIG. 12A) and with simultaneous transmission from the volumecoil and the array (FIG. 12B) using a transmit power ratio of 2:1between the volume coil and the array, respectively. The transmit B₁field is substantially more homogeneous than that obtained by the volumecoil alone in the regions covered by the array. Increasing the number ofCRC coils to 8, or increasing the diameter of the existing 4 coils wouldeliminate the residual low B₁ regions seen between the coils. To mimicconditions seen at the higher magnetic field of 7 T in the human head,where the B₁ varies by more than 75% (26), a large 3 L spherical phantomwas used (o.d. 21.5 cm, filled with 50 mM NaCl). RF power was split in a1:1 ratio between the TEM and the phased array. Again, the transmit B₁field obtained using the TEM and the CRC array simultaneously (FIG. 13B)was more homogeneous than that obtained by the TEM coil alone.Additionally, the power required to achieve an average rotation of 90°across the head was the same either during simultaneous transmission orusing the TEM coil alone.

Previously, RF field inhomogeneity corrections at high magnetic fields(above 4 T) have been demonstrated by using phased arrays (18) ormulti-port driven volume coils (32). These methods improve RF fieldhomogeneity due to combining a second commonly used mode with higherorder modes, which are intrinsically characterized by a substantiallevel of phase nonuniformity. This results in peripheral phasedistortion. Conversely, in the method disclosed herein, the TEM andphased array have similar phase distributions but different spatialprofiles. For that reason addition of two RF fields does not alter theperipheral phase distribution.

CONCLUSIONS

Phased arrays can provide enhanced SNR for peripheral brain regions incomparison to volume coils. However, due to the B₁ profile of the array,the improvement in SNR is often minimal at the center of the head. Thislimitation can be overcome if both the volume coil and the array can beused for simultaneous reception. Due to the strong interaction betweenconventional single-loop surface coils within the array and the volumecoil, and the resulting distortion in B₁ fields, simultaneous receptionhas not been widely used. To minimize the interaction between thesurface coils and the volume coils, phased arrays consisting of counterrotating current (CRC) surface coils (two parallel rings carryingopposite currents), were utilized in the present invention.

This work also describes the design and construction of CRC phasedarrays for simultaneous reception with a head-sized quadraturetransverse electromagnetic (TEM) (12) volume coil. This method has beenapplied to extend the region of enhanced sensitivity for an occipitallobe phased array and a whole brain circumscribing array for imaging at,e.g., 4 T. Specifically, 1) the performance of the individual CRC coilhas been characterized as a function of the distance between the loops;2) the spatial profile of the “optimized” CRC coil has been compared tothat of a conventional single-turn surface coil of the same size; 3) theperformance of a circumscribing CRC array has been compared to that of asimilar array of single turn-surface coils and 4) increased SNR (˜40%)afforded by simultaneous reception with the CRC array and the volumecoils has been demonstrated for central brain regions using both anoccipital array and a circumscribing array.

CRC surface coil arrays for 4 T MRSI of the human brain have beendeveloped and are disclosed herein. The CRC coils provide sensitivitysimilar to conventional single-turn surface coil and can be usedsimultaneously with the homogeneous transmit volume coil for reception.No active detuning of the transmit volume coil is required due tointrinsic isolation of the CRC and volume coils which substantiallysimplifies the transmit volume coil design and construction.

The critical Q_(U)/Q_(L) ratio of about 2, measured in this work for CRCcoils of two different sizes, characterizes the point below which wheresensitivity of the CRC coil is substantially decreased. This is animportant result in that for optimal CRC coil performance sample lossesonly need to be equivalent to intrinsic coil losses, which is arelatively easy criteria to satisfy. Although the method describedherein provides a simple recipe for CRC coil evaluation and adjustment,it is noteworthy that the value obtained is empirical and may changedepending on the CRC coil size and geometry. Also since at higher fieldsthe surface coil sensitivity profile can be modified by RF field/tissueinteraction this result may also be field dependent. Since thecontribution of the sample loss, an important factor for optimization ofCRC coils, becomes more pronounced at higher frequency, CRC coils mayprovide great potential in high-field imaging and spectroscopy of humanbody and brain.

The four-channel circumscribing CRC phased array and a quadraturehead-sized TEM volume coil disclosed herein is capable of simultaneoustransmission and reception. Using this system enables substantialimprovements in the homogeneity of the transmit B₁ profile as comparedto the volume coil alone, which becomes more pronounced with increasingfield strength. Further improvements in B₁ field homogeneity should beobtained with larger numbers of surface coils in the phased array.

REFERENCES

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1. A surface coil array for simultaneous reception of a radio frequencymagnetic field signal with a volume coil during imaging, the arraycomprising a plurality of counter rotating current (CRC) coils arrangedfor positioning over the surface of a region to be imaged, wherein eachCRC coil contains two parallel loops in separate parallel planes wherecurrent flows in opposite direction in each loop, wherein the CRC coilarray is intrinsically decoupled from the volume coil due to thepresence of two counter rotating loops in separate parallel planes ineach coil, and wherein the CRC coil array provides simultaneousreception of the radio frequency magnetic field signal with the volumecoil during imaging.
 2. A method of imaging a region of a subjectcomprising simultaneously receiving a radio frequency magnetic field bythe surface coil array of claim 1 and by a volume coil.
 3. A surfacecoil phased array for simultaneous transmission and reception of a radiofrequency magnetic field signal with a quadrature volume coil duringimaging, the array comprising at least four counter rotating current(CRC) coils uniformly arranged for positioning around the surface of aregion to be imaged, wherein each CRC coil contains two parallel loopsin separate parallel planes where current flows in opposite direction ineach loop, wherein the CRC coil array is intrinsically decoupled fromthe volume coil due to the presence of two counter rotating loops inseparate parallel planes in each coil, wherein the radio frequencymagnetic field transmitted by an individual coil is shifted out of phasewith the radio frequency magnetic field transmitted by adjacent coils toproduce a circularly polarized radio frequency magnetic field that is inphase with a circularly polarized radio frequency magnetic fieldgenerated by the quadrature volume coil, and wherein the CRC coil phasedarray provides simultaneous transmission and reception of the radiofrequency magnetic field signal with the volume coil during imaging. 4.The surface coil array of claim 1 or 3, wherein distance between loopsof each coil is adjusted to optimize i) decoupling between CRC surfacecoils in the array and the volume coil and ii) sensitivity of the CRCcoil for reception.
 5. The surface coil array of claim 1 or 3, whereindistance between loops of each coil is optimized according to coilgeometry and imaging conditions.
 6. The surface coil array of claim 5,wherein distance between loops is optimized according to the diameter ofloop and the resonance frequency of the coil.
 7. The surface coil arrayof claim 1 or 3, wherein the array has a ratio Q_(U)/Q_(L) between theunloaded Q-factor (Q_(U)) and the loaded Q-factor (Q_(L)) of at least2.0, whereQ_(L)=ω₀ W _(t) /P _(sample) +P _(coil) and Q _(U)=ω₀ W _(t)/P _(coil),ω₀ is the resonance frequency, W_(t) is the total magnetic field energy,and P_(sample) and P_(coil) are sample and coil energy losses,respectively.
 8. The surface coil array of claim 1 or 3, whereinpreamplifier decoupling of the CRC coils is used to reduce volume coilradio frequency magnetic field distortions.
 9. The surface coil array ofclaim 1 or 3, wherein simultaneous reception of the radio frequencymagnetic field by the surface coil array and by the volume coil resultsin an increase in signal-to-noise ratio (SNR) up to square root of 2 inareas where the surface coils and the volume coil have similarsensitivity, compared to the SNR obtained by the volume coil or by thesurface coil array in the absence of simultaneous reception.
 10. Thesurface coil array of claim 3, wherein homogeneity of the transmittedradio frequency magnetic field is improved by simultaneous transmissionof the radio frequency magnetic field by the surface coil array and bythe volume coil, compared to the homogeneity in the absence ofsimultaneous transmission.
 11. A radio frequency (RF) system for imagingcomprising the surface coil array of claim 1 or 3, and a quadraturevolume coil.
 12. The RF system of claim 11, which further comprisespreamplifier decoupling of the CRC coils.
 13. A method of imaging aregion of a subject comprising simultaneously transmitting and receivinga radio frequency magnetic field by the surface coil phased array ofclaim 3 and by a quadrature volume coil.
 14. The method of claim 2 or13, wherein simultaneous reception of the radio frequency magnetic fieldby the surface coil array and by the volume coil results in an increasein signal-to-noise ratio (SNR) up to square root of 2 in areas where thesurface coils and the volume coil have similar sensitivity, compared tothe SNR obtained by the volume coil or by the surface coil array in theabsence of simultaneous reception.
 15. The method of claim 13, whereinhomogeneity of the transmitted radio frequency field is improved bysimultaneous transmission of the radio frequency field by the surfacecoil array and by the volume coil, compared to the homogeneity in theabsence of simultaneous transmission.
 16. The method of claim 2 or 13,which further comprises preamplifier decoupling of the CRC coils toreduce volume coil radio frequency magnetic field distortions.
 17. Themethod of claim 2 or 13, wherein a central brain region is imaged.